Pharma & Specialty Chemical Standards

Amlodipine, IUPAC name (±)-3-ethyl-5-methyl-2-(2-aminoethoxy)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid methyl ester, is a dihydropyridine calcium channel blocker. Molecular formula C20H26N2O5S, molecular weight 406.48 g/mol. It features a 1,4-dihydropyridine core with hydrophobic substituents. Therapeutically used for hypertension and angina. Physicochemical properties include lipophilicity, low water solubility, and high plasma protein binding. Mechanism of action involves selective inhibition of L-type voltage-dependent calcium channels in vascular smooth muscle, reducing intracellular calcium influx and promoting vasodilation.