Pharma & Specialty Chemical Standards

Anastrozole, IUPAC name 4-(4-cyano-3-trifluoromethylphenyl)-1H-1,2,4-triazole-1-ethanol, is a non-steroidal aromatase inhibitor with molecular formula C13H9FN4O and molecular weight 256.24 g/mol. It belongs to the triazole class, featuring a five-membered ring fused to a benzene ring substituted with cyano and trifluoromethyl groups. Therapeutically used in postmenopausal breast cancer treatment, it exhibits low water solubility and high lipophilicity. Mechanism of action involves irreversible binding to the aromatase enzyme, inhibiting androgen-to-estrogen conversion, thereby reducing estrogen-dependent tumor growth.