Pharma & Specialty Chemical Standards

Clobetasol, a synthetic glucocorticoid corticosteroid, is chemically designated as 6-Chloro-11β,17α,21-trihydroxy-9-fluoro-16α-methylpregna-1,4-diene-3,20-dione (IUPAC name), with molecular formula C₂₂H₂₉ClF₂O₅ and molecular weight 446.45 g/mol. Structurally, it features a pregnane backbone with 9-fluoro, 6-chloro, and 16α-methyl substitutions, enhancing anti-inflammatory potency. Therapeutically, it treats severe dermatological conditions like eczema and psoriasis. It is a white to off-white crystalline solid, sparingly soluble in water but soluble in organic solvents. Mechanistically, it binds glucocorticoid receptors, translocates to the nucleus, and modulates gene transcription to suppress inflammatory and immune responses.