2NP-AHD is a substituted furan derivative containing a 2-nitrophenyl group linked to a 5-amino-1H-1,2,4-triazole-3-carboxylic acid hydrazide moiety. The core structure features a five-membered furan ring fused with a nitro-substituted aromatic system, with an amino group at the triazole ring and a hydrazide functional group. This impurity arises during the synthetic pathway of nitrofuran-based antibiotics via nucleophilic aromatic substitution. It serves as a critical HPLC reference standard for quantifying process-related impurities in parent drug formulations.
On RequestC1C(=O)NC(=O)N1/N=C/C2=CC=CC=C2[N+](=O)[O-]
InChI=1S/C10H8N4O4/c15-9-6-13(10(16)12-9)11-5-7-3-1-2-4-8(7)14(17)18/h1-5H,6H2,(H,12,15,16)/b11-5+
FULJCJZKZXOFQZ-VZUCSPMQSA-N