4-Hydroxy propranolol Hydrochloride
4-Hydroxy propranolol Hydrochloride is a structurally modified derivative of propranolol, featuring a hydroxyl group at the 4-position of the benzene ring. This substitution introduces a polar hydroxyl functionality adjacent to the isopropylamino side chain, altering the compound's physicochemical properties compared to the parent drug. The hydrochloride salt form enhances solubility and stability. This impurity arises via oxidative degradation pathways, commonly observed during propranolol synthesis or storage under stressed conditions. It serves as a critical HPLC reference standard for quantifying specific impurities in propranolol-containing pharmaceuticals.
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Molecular Formula
C16H21NO3
Molecular Weight
275.3400
CAS Number
10476-53-6
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PubChem CID
91565 ↗
IUPAC Name
4-[2-hydroxy-3-(propan-2-ylamino)propoxy]naphthalen-1-ol
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📝 Synonyms
4-Hydroxypropranolol
10476-53-6
2449QP4SVP
1-(4-Hydroxynaphth-1-yloxy)-3-isopropylamino-2-propanol
4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)-1-naphthalenol
RefChem:905500
(+-)-4-Hydroxypropranolol
4'-hydroxypropanolol
4-[2-hydroxy-3-(propan-2-ylamino)propoxy]naphthalen-1-ol
(+/-)-4-HYDROXYPROPRANOLOL
🔬 Chemical Identifiers
CC(C)NCC(COC1=CC=C(C2=CC=CC=C21)O)O
InChI=1S/C16H21NO3/c1-11(2)17-9-12(18)10-20-16-8-7-15(19)13-5-3-4-6-14(13)16/h3-8,11-12,17-19H,9-10H2,1-2H3
CWEPACWBWIOYID-UHFFFAOYSA-N
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