Aprepitant M2 Metabolite
Aprepitant M2 Metabolite (CAS: 380499-06-9, Formula: C20H18F7NO2) is a known metabolic product of Aprepitant, an antiemetic neurokinin-1 (NK1) receptor antagonist. This compound functions as a crucial API impurity, critical for ensuring the purity, safety, and regulatory compliance of Aprepitant in pharmaceutical formulations. Its characterization is essential for comprehensive drug substance and product quality control.
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Molecular Formula
C20H18F7NO2
Molecular Weight
437.4000
CAS Number
380499-06-9
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PubChem CID
11826258 ↗
IUPAC Name
(2R,3R)-2-((1R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluoro phenyl) morpholine
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📝 Synonyms
380499-06-9
(2R,3R)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine
(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
V6NA9JEV32
SCHEMBL271095
AFBDSAJOMZYQAI-HWOJHCLVSA-N
(2R)-2alpha-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3beta-(4-fluorophenyl)morpholine
Aprepitant Impurity B
Retigabine Dihydrochloride Impurity B
2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine, (2R,3R)-
🔬 Chemical Identifiers
FC(C=1C=C(C=C(C1)C(F)(F)F)[C@@H](C)O[C@@H]1[C@H](NCCO1)C1=CC=C(C=C1)F)(F)F
InChI=1S/C20H18F7NO2/c1-11(13-8-14(19(22,23)24)10-15(9-13)20(25,26)27)30-18-17(28-6-7-29-18)12-2-4-16(21)5-3-12/h2-5,8-11,17-18,28H,6-7H2,1H3/t11-,17-,18-/m1/s1
AFBDSAJOMZYQAI-HWOJHCLVSA-N
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