Artemether EP Impurity C
Artemether EP Impurity C is a synthetic byproduct arising from the hydrolytic cleavage of the methyl ether moiety in Artemether, resulting in a free hydroxyl group at the corresponding position. Retaining the core sesquiterpene lactone framework and peroxide bridge characteristic of the parent compound, this impurity exhibits altered polarity due to the hydroxyl substitution. It serves as a critical HPLC reference standard for quantifying this specific degradation pathway in Artemether drug substance purity profiling.
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Molecular Formula
C16H26O5
Molecular Weight
298.3700
CAS Number
181528-64-3
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PubChem CID
15812603 ↗
IUPAC Name
[(3aS,4R,6aS,7R,8S,10R,10aR)-8-methoxy-4,7-dimethyl-2,3,3a,4,5,6,6a,7,8,10-decahydrofuro[3,2-i]isochromen-10-yl] acetate
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📝 Synonyms
181528-64-3
2H,10H-Furo[3,2-i]-2-benzopyran-10-ol, octahydro-8-methoxy-4,7-dimethyl-, 10-acetate, (3aS,4R,6aS,7R,8S,10R,10aR)-
2H,10H-Furo(3,2-i)-2-benzopyran-10-ol, octahydro-8-methoxy-4,7-dimethyl-, 10-acetate, (3aS,4R,6aS,7R,8S,10R,10aR)-
RefChem:267521
Artemether Impurity C
Artemether Tetrahydrofuran Acetate
[(3As,4R,6aS,7R,8S,10R,10aR)-8-methoxy-4,7-dimethyl-2,3,3a,4,5,6,6a,7,8,10-decahydrofuro[3,2-i]isochromen-10-yl] acetate
(1R,5S,6R,9S,10R,11S,13R)-11-methoxy-6,10-dimethyl-2,12-dioxatricyclo[7.4.0.0?,?]tridecan-13-yl acetate
(3aS,4R,6aS,7R,8S,10R,10aR)-Octahydro-8-methoxy-4,7-dimethyl-2H,10H-furo[3,2-i][2]benzopyran-10-ol 10-Acetate, ; [3aS-(3aa,4a,6aa,7ss,8ss,10a,10aS*)]-Octahydro-8-methoxy-4,7-dimethyl-2H,10H-furo[3,2-i][2]benzopyran-10-ol Acetate; Artemether Ph. Int. Impurity C
Artemether Impurity 2
🔬 Chemical Identifiers
C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@@H]([C@@]23[C@H]1CCO3)OC(=O)C)OC)C
InChI=1S/C16H26O5/c1-9-5-6-13-10(2)14(18-4)21-15(20-11(3)17)16(13)12(9)7-8-19-16/h9-10,12-15H,5-8H2,1-4H3/t9-,10-,12+,13+,14+,15+,16-/m1/s1
PJRDDUABDHLSPP-QYHITDJBSA-N
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