daclatasvir SSSR

Daclatasvir SSSR is a process-related impurity arising from the synthetic pathway of daclatasvir, characterized by a truncated dibenzofuran core with a retained pyridine-3-ylmethyl substituent but lacking the terminal cyclopropylmethyl sulfonamide moiety. Its structure features a 2,6-dichlorobenzoyl group conjugated to a 4-amino-1H-benzimidazole scaffold, forming a planar, rigid system with enhanced hydrophobicity compared to the parent compound. This impurity originates from an early-stage coupling reaction, where incomplete alkylation of the benzimidazole ring precursor occurs. The absence of the cyclopropylmethyl chain reduces steric hindrance, altering its pharmacokinetic profile. Serves as a critical HPLC reference standard for impurity profiling in daclatasvir active pharmaceutical ingredient (API) batches.