EFINACONAZOLE Impurity
Efinaconazole impurity is a structurally related synthetic byproduct arising from incomplete alkylation during triazole ring formation. It retains the core 1H-1,2,4-triazole scaffold and 4-fluorophenyl substituent but features a truncated propyl chain with a terminal hydroxymethyl group instead of the parent drug's secondary alcohol. This positional isomer exhibits distinct HPLC retention due to altered hydrophobicity, serving as a critical reference standard for quantifying process-derived impurities in efinaconazole bulk drug substance analysis.
On Request
IUPAC Name
1-(2-bromo-5-fluorophenyl)-1,2,4-triazole
📝 Synonyms
Efinaconazole Impurity
909274-76-6
SCHEMBL4040514
WSTLTCNVGOYIRO-UHFFFAOYSA-N
1-(2-bromo-5-fluorophenyl)-1H-1,2,4-triazole
🔬 Chemical Identifiers
C1=CC(=C(C=C1F)N2C=NC=N2)Br
InChI=1S/C8H5BrFN3/c9-7-2-1-6(10)3-8(7)13-5-11-4-12-13/h1-5H
WSTLTCNVGOYIRO-UHFFFAOYSA-N
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