Ethyl sofosbuvir
Ethyl sofosbuvir is a structurally related impurity derived from the antiviral nucleotide analog sofosbuvir, characterized by an ethyl substitution on the uracil core’s 4-amino group. This modification disrupts the parent compound’s phosphoramidate prodrug functionality, rendering it inert to viral NS5B polymerase. The molecule retains the 2’-C-methyl-β-D-ribofuranose sugar moiety and cyclopropyl terminus critical for binding specificity. Synthetically, it arises as a byproduct during alkylation steps in sofosbuvir production. It serves as an HPLC reference standard for quantifying process-related impurities in sofosbuvir active pharmaceutical ingredients.
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