fexofenadine Imp-E
Fexofenadine Imp-E is a dehydroxylated analog of the parent antihistamine, characterized by a substituted benzimidazole core linked to a piperidine ring via a methylene bridge. The absence of the carboxylic acid moiety present in fexofenadine results in a reduced molecular weight and altered hydrophobicity. This impurity arises during synthetic pathways involving incomplete oxidation of the benzimidazole precursor. It serves as a critical HPLC reference standard for quantifying process-related impurities in fexofenadine APIs.
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Molecular Formula
C18H21NO
Molecular Weight
267.4000
CAS Number
115-46-8
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PubChem CID
15723 ↗
IUPAC Name
diphenyl(piperidin-4-yl)methanol
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📝 Synonyms
Azacyclonol
115-46-8
diphenyl(piperidin-4-yl)methanol
gamma-Pipradol
Azaciclonolo
Azacyclonolum
azaciclonol
2MMR990PEM
DTXSID2045280
DTXCID0025280
🔬 Chemical Identifiers
C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O
InChI=1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2
ZMISODWVFHHWNR-UHFFFAOYSA-N
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