Fosaprepitant Methyl Ester Impurity
Fosaprepitant Methyl Ester Impurity is a structural analog of the neurokinin-1 (NK1) receptor antagonist prodrug, Fosaprepitant. It features the core aprepitant scaffold, characterized by fluorinated aromatic rings, a tetrazole moiety, and an amide linkage. Unlike Fosaprepitant, which possesses a phosphonooxymethyl group containing a dihydrogen phosphate, this impurity exhibits a methyl esterification on one of the phosphate hydroxyls, resulting in a monomethyl phosphate ester. This modification alters the polarity and reactivity compared to the parent prodrug. It serves as an essential analytical reference standard for the qualification and quantification of process-related impurities in Fosaprepitant API manufacturing.
On Request📝 Synonyms
🔬 Chemical Identifiers
FC(C=1C=C(C=C(C1)C(F)(F)F)[C@@H](C)O[C@H]1OCCN([C@H]1C1=CC=C(C=C1)F)CC(=N)NNC(=O)OC)(F)F
InChI=1S/C24H25F7N4O4/c1-13(15-9-16(23(26,27)28)11-17(10-15)24(29,30)31)39-21-20(14-3-5-18(25)6-4-14)35(7-8-38-21)12-19(32)33-34-22(36)37-2/h3-6,9-11,13,20-21H,7-8,12H2,1-2H3,(H2,32,33)(H,34,36)/t13-,20+,21-/m1/s1
JMBSYJOVXPFTFD-HBUDHLSFSA-N
Dimeglumine.png)
Dimeglumine.png)
