Fosaprepitant (S, R, S)Dimeglumine
This compound, Fosaprepitant (S,R,S)Dimeglumine, presents as a specific stereoisomer of the NK1 receptor antagonist prodrug, Fosaprepitant. Characterized by the C30H39F7N5O11P empirical formula, it exhibits an altered stoichiometric composition relative to standard Fosaprepitant monomeglumine, specifically a deficit of one nitrogen atom and an excess of three oxygen atoms. This suggests a significant structural modification within the core Fosaprepitant moiety, potentially involving oxidative degradation or hydrolysis of nitrogenous functional groups like the triazole ring, alongside its distinct (S,R,S) configuration at the morpholine and side-chain chiral centers. It is utilized as a crucial analytical reference standard for impurity profiling during Fosaprepitant API quality control.
On Request📝 Synonyms
🔬 Chemical Identifiers
FC(C=1C=C(C=C(C1)C(F)(F)F)[C@H](C)O[C@H]1OCCN([C@H]1C1=CC=C(C=C1)F)CC=1NN(C(N1)=O)P(O)(O)=O)(F)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
InChI=1S/C23H22F7N4O6P.C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);4-13H,2-3H2,1H3/t12-,19-,20+;4-,5+,6+,7+/m00/s1
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Dimeglumine.png)
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