Lidocaine impurity E
Lidocaine impurity E is a process-related synthetic byproduct arising from incomplete alkylation during the formation of the diethylamino moiety in Lidocaine synthesis. It retains the 2,6-dimethylphenyl ring but features a monoethylamino substituent in place of the fully alkylated diethylamino group, resulting in a primary amine functionality. This structural deviation creates a distinct polarity profile, enabling chromatographic differentiation from the parent compound. The impurity serves as a critical HPLC reference standard for quantifying alkylation efficiency in API manufacturing processes.
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IUPAC Name
2-[[2-(2,6-dimethylanilino)-2-oxoethyl]amino]-N-(2,6-dimethylphenyl)acetamide
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📝 Synonyms
745798-07-6
Lidocaine Impurity E
2,2'-Iminobis(N-(2,6-dimethylphenyl)acetamide)
Lidocaine EP Impurity E
2,2'-Azanediylbis(N-(2,6-dimethylphenyl)acetamide)
Lidocaine impurity E [EP]
2-[[2-(2,6-dimethylanilino)-2-oxoethyl]amino]-N-(2,6-dimethylphenyl)acetamide
N-(2,6-dimethylphenyl)-2-({[(2,6-dimethylphenyl)carbamoyl]methyl}amino)acetamide
8P3T7VI89U
Acetamide, 2,2'-iminobis(N-(2,6-dimethylphenyl)-
🔬 Chemical Identifiers
CC1=C(C(=CC=C1)C)NC(=O)CNCC(=O)NC2=C(C=CC=C2C)C
InChI=1S/C20H25N3O2/c1-13-7-5-8-14(2)19(13)22-17(24)11-21-12-18(25)23-20-15(3)9-6-10-16(20)4/h5-10,21H,11-12H2,1-4H3,(H,22,24)(H,23,25)
UMQJGNLKESQUOD-UHFFFAOYSA-N
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