Metformin EP Impurity E
Metformin EP Impurity E is a structurally related biguanide derivative arising from incomplete alkylation during Metformin synthesis. It retains a dimethylamino group but lacks the second methyl substitution on the guanidine moiety, resulting in a primary amine functionality adjacent to the amidine core. This impurity exhibits distinct HPLC retention due to its reduced hydrophobicity compared to the parent drug. It serves as a critical HPLC reference standard for quantifying this specific synthetic byproduct in Metformin API batches.
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IUPAC Name
1-(diaminomethylidene)-2-methylguanidine
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📝 Synonyms
DTXSID10167032
RefChem:76370
DTXCID4089523
Metformin hydrochloride impurity E
1-METHYL-BIGUANIDE
1-Methylbiguanide
1609-00-3
Biguanide, 1-methyl-
IMIDODICARBONIMIDIC DIAMIDE, N-METHYL-
K9BB0L32CH
🔬 Chemical Identifiers
CN=C(N)N=C(N)N
InChI=1S/C3H9N5/c1-7-3(6)8-2(4)5/h1H3,(H6,4,5,6,7,8)
JLPWQEHTPOFCPG-UHFFFAOYSA-N
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