Naproxen Sodium impurity E
Naproxen Sodium impurity E is a structural analog of the parent drug, featuring a naphthalene core substituted with a methoxy group at the 6-position and a propanoic acid side chain. Its distinct configuration arises from a synthetic byproduct pathway involving ethylation rather than methylation during naphthalene ring functionalization. The compound retains the carboxylic acid moiety critical for pharmacological activity but exhibits altered hydrophobicity due to an extended aliphatic chain. This impurity serves as an HPLC reference standard for quantifying process-related deviations in Naproxen Sodium synthesis.
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Molecular Formula
C15H16O3
Molecular Weight
244.2800
CAS Number
26159-35-3
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PubChem CID
9899603 ↗
IUPAC Name
methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
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Official Reference Standards
| Std | Catalog # | Quantity | Price |
|---|---|---|---|
| USP | 1457356 ↗ | 25 mg | USD 838.00 |
📝 Synonyms
26159-35-3
(S)-Naproxen Methyl Ester
Naproxen Methyl Ester
Methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
(+)-Naproxen Methyl Ester
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, methyl ester, (alphaS)-
Naproxen impurity E [EP]
571OJX4PDN
Naproxen sodium impurity E [EP]
DTXSID50180780
🔬 Chemical Identifiers
C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OC
InChI=1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3/t10-/m0/s1
ZFYFBPCRUQZGJE-JTQLQIEISA-N
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