Olmesartan Impurity 6
Olmesartan Impurity 6 is a process-related byproduct formed during the synthesis of olmesartan medoxomil via amidation of 4’-chlorobiphenyl-2-carboxylic acid. It retains the biphenyl core but lacks the tetrazole ring, featuring instead a substituted pyridine moiety linked through an amide bond. The compound exhibits a hydroxyl group at the 5-position of the pyridine and a methoxy ester functionality, distinguishing it from the parent drug’s angiotensin II receptor antagonist structure. This impurity arises from premature termination of the tetrazole-forming cascade, serving as a key HPLC reference standard for monitoring synthetic pathway efficiency.
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Molecular Formula
C11H16N2O3
Molecular Weight
224.2600
CAS Number
144690-07-3
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PubChem CID
10513320 ↗
IUPAC Name
ethyl 4-acetyl-2-propyl-1H-imidazole-5-carboxylate
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📝 Synonyms
144690-07-3
ethyl 4-acetyl-2-propyl-1H-imidazole-5-carboxylate
Ethyl 5-acetyl-2-propyl-1H-imidazole-4-carboxylate
MFCD18910535
5-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester
1H-Imidazole-4-carboxylic acid, 5-acetyl-2-propyl-, ethyl ester
1H-Imidazole-5-carboxylic acid, 4-acetyl-2-propyl-, ethyl ester
5-Acetyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
ethyl 4-acetyl-2-propylimidazole-5-carboxylate
Olmesartan Impurity 38
🔬 Chemical Identifiers
CCCC1=NC(=C(N1)C(=O)OCC)C(=O)C
InChI=1S/C11H16N2O3/c1-4-6-8-12-9(7(3)14)10(13-8)11(15)16-5-2/h4-6H2,1-3H3,(H,12,13)
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