Propranolol impurity B
Propranolol impurity B is a dimeric byproduct formed via coupling of two propranolol molecules through an ether linkage at the naphthol moiety, yielding a bis(naphthyl)propanolamine structure with an extended conjugated system and retained β-adrenergic antagonist framework. This impurity functions as an HPLC reference standard for quantifying synthetic byproducts in propranolol API batches.
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Molecular Formula
C29H33NO4
Molecular Weight
459.6000
CAS Number
83314-78-7
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PubChem CID
13357172 ↗
IUPAC Name
1-[(2-hydroxy-3-naphthalen-1-yloxypropyl)-propan-2-ylamino]-3-naphthalen-1-yloxypropan-2-ol
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Official Reference Standards
| Std | Catalog # | Quantity | Price |
|---|---|---|---|
| USP | 1A19110 ↗ | 25 mg | USD 429.00 |
📝 Synonyms
83314-78-7
Tertiary amine derivative
M6FSA99797
Propranolol hydrochloride impurity B [EP]
1,1-((1-Methylethyl)imino)bis(3-(naphthalen-1-yloxy)propan-2-ol)
2-Propanol, 1,1'-((1-methylethyl)imino)bis(3-(1-naphthalenyloxy)-
2-Propanol, 1,1'-[(1-methylethyl)imino]bis[3-(1-naphthalenyloxy)-
PROPRANOLOL HYDROCHLORIDE IMPURITY B [EP IMPURITY]
PROPRANOLOL HYDROCHLORIDE IMPURITY B (EP IMPURITY)
RefChem:196649
🔬 Chemical Identifiers
CC(C)N(CC(COC1=CC=CC2=CC=CC=C21)O)CC(COC3=CC=CC4=CC=CC=C43)O
InChI=1S/C29H33NO4/c1-21(2)30(17-24(31)19-33-28-15-7-11-22-9-3-5-13-26(22)28)18-25(32)20-34-29-16-8-12-23-10-4-6-14-27(23)29/h3-16,21,24-25,31-32H,17-20H2,1-2H3
MKZHJJQCUIZEDE-UHFFFAOYSA-N
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