R-Mitiglinide
R-Mitiglinide is the enantiomerically pure R-configured stereoisomer of the antihypertensive agent Mitiglinide, characterized by a 2-(3-pyridylmethyl)-5-(2-nitrophenyl)pyrrolidin-3-one core with a single chiral center at the pyrrolidinone C-2 position. Its structural features include a nitro-substituted aromatic ring, a pyridine-linked alkyl chain, and a lactam functionality. As the non-pharmacologically active enantiomer of S-Mitiglinide, it arises as a synthetic byproduct during racemic resolution processes. This compound serves as an HPLC reference standard for quantifying enantiomeric purity in Mitiglinide API batches.
On Request
IUPAC Name
(2R)-4-[(3aS,7aR)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-2-benzyl-4-oxobutanoic acid
📝 Synonyms
145375-44-6
Mitiglinide Impurity 5
(R)-2-benzyl-4-((3aR,7aS)-octahydro-2H-isoindol-2-yl)-4-oxobutanoic acid
R-Mitiglinide
Mitiglinide, R-
SCHEMBL4457953
FZ2QA67799
(alphaR,3aR,7aS)-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid
2H-Isoindole-2-butanoic acid, octahydro-gamma-oxo-alpha-(phenylmethyl)-, (alphaR,3aR,7aS)-
Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid, (alphaR,3aR,7aS)-
🔬 Chemical Identifiers
C1CC[C@H]2CN(C[C@H]2C1)C(=O)C[C@@H](CC3=CC=CC=C3)C(=O)O
InChI=1S/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23)/t15-,16+,17-/m1/s1
WPGGHFDDFPHPOB-IXDOHACOSA-N
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