Tolterodine impurity E
Tolterodine impurity E is a structurally related synthetic byproduct arising from incomplete ring closure during the formation of the dibenzothiazepine core in Tolterodine synthesis. It retains the piperidine-based tertiary amine moiety but lacks the sulfur atom of the thiazepine ring, substituting it with a saturated aliphatic chain containing a hydroxyl group. This impurity exhibits a distinct NMR signature due to its open-chain configuration and reduced aromatic conjugation compared to the parent compound. It serves as a critical HPLC reference standard for quantifying process-derived impurities in Tolterodine active pharmaceutical ingredients.
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Molecular Formula
C19H25NO
Molecular Weight
283.4000
CAS Number
480432-14-2
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PubChem CID
9857017 ↗
IUPAC Name
4-methyl-2-[1-phenyl-3-(propan-2-ylamino)propyl]phenol
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Official Reference Standards
| Std | Catalog # | Quantity | Price |
|---|---|---|---|
| EP | Y0001699 ↗ | 15 MG | EUR 90.00 |
📝 Synonyms
480432-14-2
N-Isopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine
rac Desisopropyl Tolterodine
Tolterodine EP Impurity E
4-methyl-2-[1-phenyl-3-(propan-2-ylamino)propyl]phenol
956HC7TAM9
UNII-956HC7TAM9
PHENOL, 4-METHYL-2-[3-[(1-METHYLETHYL)AMINO]-1-PHENYLPROPYL]-
Tolterodine tartrate impurity E [EP]
2-[3-(Isopropylamino)-1-phenylpropyl]-4-methylphenol
🔬 Chemical Identifiers
CC1=CC(=C(C=C1)O)C(CCNC(C)C)C2=CC=CC=C2
InChI=1S/C19H25NO/c1-14(2)20-12-11-17(16-7-5-4-6-8-16)18-13-15(3)9-10-19(18)21/h4-10,13-14,17,20-21H,11-12H2,1-3H3
CPLYUIYTJCFQJD-UHFFFAOYSA-N
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